Intermediate filaments

Transport of VIF in RPE Cells.gif
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Vimentin aggregates in GAN KO cells
Vimentin aggregates in GAN KO cells

Inhibited transport of intermediate filaments is the underlying reason for their aggregation in the Giant axonal neuropathy disorder. Distribution of vimentin and microtubule in control (upper cell) and GAN KO (lower) cells

Model of microtubule-microtubule sliding driven by kinesin-1. Kinesin-1 slides antiparallel microtubules apart with their minus-ends leading (left panel). When kinesin-1 binds to parallel microtubules (right panel), forces applied by the two motors
During late oogenesis, Drosophila oocyte cytoplasm undergoes circular movement called ooplasmic streaming. Posterior determinants containing the fluorescently labeled marker Staufen move with the cytoplasmic flow, but dramatically slow down near the