Publications
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List of publications in the last 5 years
Go with the flow - bulk transport by molecular motors. Wen Lu 1, Vladimir I Gelfand. J Cell Sci 2023 Mar 1;136(5):jcs260300. doi: 10.1242/jcs.260300
Gigaxonin is required for intermediate filament transport. Renganathan B, Zewe JP, Cheng Y, Paumier JM, Kittisopikul M, Ridge KM, Opal P, Gelfand VI. FASEB J. 2023 May;37(5):e22886. doi: 10.1096/fj.202202119R.
Go with the flow – bulk transport by molecular motors. Wen Lu , Vladimir I Gelfand. J Cell Sci. 2023 Mar 1;136(5):jcs260300. doi: 10.1242/jcs.260300.
A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary. W Lu, M Lakonishok, AS Serpinskaya, VI Gelfand. Elife. 2022 Feb 16;11:e75538. doi: 10.7554/eLife.75538.
Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila. Urko del Castillo, Rosalind Norkett, WenLu, Anna Serpinskaya, Vladimir I.Gelfand. iScience Volume 25, Issue 1, 21 January 2022, 103536. https://www.sciencedirect.com/science/article/pii/S2589004221015078.
Gatekeeper function for Short stop at the ring canals of the Drosophila ovary. Wen Lu, Margot Lakonishok, Vladimir I.Gelfand.Current Biology 31, 1–14 August 9, 2021. https://doi.org/10.1016/j.cub.2021.05.010
Kinetochore protein Spindly controls microtubule polarity in Drosophila axons. del Castillo U, Müller HJ, Gelfand VI. Proc Natl Acad Sci U S A. 2020 May 19:202005394. doi: 10.1073/pnas.2005394117 PMID: 32430325
Competition between kinesin-1 and myosin-V defines Drosophila posterior determination. Lu W, Lakonishok M, Liu R, Billington N, Rich A, Glotzer M, Sellers JR, Gelfand VI. Elife. 2020 Feb 14;9. pii: e54216. doi: 10.7554/eLife.54216
Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding. Norkett R, Del Castillo U, Lu W, Gelfand VI. Elife. 2020 Feb 5;9. pii: e52009. doi: 10.7554/eLife.52009.
Unconventional Roles of Cytoskeletal Mitotic Machinery in Neurodevelopment. Del Castillo U, Norkett R, Gelfand VI. Trends Cell Biol. 2019 Nov;29(11):901-911. doi: 10.1016/j.tcb.2019.08.006. Epub 2019 Oct 6. Review. PMID: 31597609 Similar articles
Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics. Del Castillo U, Gnazzo MM, Sorensen Turpin CG, Nguyen KCQ, Semaya E, Lam Y, de Cruz MA, Bembenek JN, Hall DH, Riggs B, Gelfand VI, Skop AR. Traffic. 2019 Jun;20(6):436-447. doi: 10.1111/tra.12647. Epub 2019 May 8.
Repurposing Kinetochore Microtubule Attachment Machinery in Neurodevelopment. Norkett R, Lu W, Gelfand VI. Dev Cell. 2019 Mar 25;48(6):746-748. doi: 10.1016/j.devcel.2019.03.004.
Microtubule Dynamics, Kinesin-1 Sliding, and Dynein Action Drive Growth of Cell Processes. Oelz DB, Del Castillo U, Gelfand VI, Mogilner A. Biophys J. 2018 Oct 16;115(8):1614-1624.
Ooplasmic flow cooperates with transport and anchorage in Drosophila oocyte posterior determination. Lu W, Lakonishok M, Serpinskaya AS, Kirchenbüechler D, Ling SC, Gelfand VI. J Cell Biol. 2018 Oct 1;217(10):3497-3511. doi: 10.1083/jcb.201709174. Epub 2018 Jul 23.
Kinesin-dependent transport of keratin filaments: a unified mechanism for intermediate filament transport. Robert A, Tian P, Adam SA, Kittisopikul M, Jaqaman K, Goldman RD, Gelfand VI. FASEB J. 2019 Jan;33(1):388-399. doi: 10.1096/fj.201800604R. Epub 2018 Jun 26.
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Elife. 2017 May 19;6. pii: e25174. doi: 10.7554/eLife.25174.
Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles. Barlan K, Gelfand VI. Cold Spring Harb Perspect Biol. 2017 May 1;9(5). pii: a025817. doi: 10.1101/cshperspect.a025817. Review.
Moonlighting Motors: Kinesin, Dynein, and Cell Polarity. Lu W, Gelfand VI. Trends Cell Biol. 2017 Jul;27(7):505-514. doi: 10.1016/j.tcb.2017.02.005. Epub 2017 Mar 8. Review.
Role of kinesin-1-based microtubule sliding in Drosophila nervous system development. Winding M, Kelliher MT, Lu W, Wildonger J, Gelfand VI. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4985-94. doi: 10.1073/pnas.1522416113. Epub 2016 Aug 10.
Microtubule-microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in Drosophila oocytes. Lu W, Winding M, Lakonishok M, Wildonger J, Gelfand VI. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4995-5004. doi: 10.1073/pnas.1522424113. Epub 2016 Aug 10.
Engineered kinesin motor proteins amenable to small-molecule inhibition. Engelke MF, Winding M, Yue Y, Shastry S, Teloni F, Reddy S, Blasius TL, Soppina P, Hancock WO, Gelfand VI, Verhey KJ. Nat Commun. 2016 Apr 5;7:11159. doi: 10.1038/ncomms11159.
Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments. Ridge KM, Shumaker D, Robert A, Hookway C, Gelfand VI, Janmey PA, Lowery J, Guo M, Weitz DA, Kuczmarski E, Goldman RD. Methods Enzymol. 2016;568:389-426. doi: 10.1016/bs.mie.2015.09.036. Epub 2015 Dec 19.
A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Jolly AL, Luan CH, Dusel BE, Dunne SF, Winding M, Dixit VJ, Robins C, Saluk JL, Logan DJ, Carpenter AE, Sharma M, Dean D, Cohen AR, Gelfand VI. Cell Rep. 2016 Jan 26;14(3):611-620. doi: 10.1016/j.celrep.2015.12.051. Epub 2016 Jan 7.
Intermediate filament dynamics: What we can see now and why it matters. Robert A, Hookway C, Gelfand VI. Bioessays. 2016 Mar;38(3):232-43. doi: 10.1002/bies.201500142. Epub 2016 Jan 13. Review.
Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts. Lowery J, Jain N, Kuczmarski ER, Mahammad S, Goldman A, Gelfand VI, Opal P, Goldman RD. Mol Biol Cell. 2016 Feb 15;27(4):608-16. doi: 10.1091/mbc.E15-09-0627. Epub 2015 Dec 23.
Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons. del Castillo U, Winding M, Lu W, Gelfand VI. Elife. 2015 Dec 28;4:e10140. doi: 10.7554/eLife.10140.
Vimentin filament precursors exchange subunits in an ATP-dependent manner. Robert A, Rossow MJ, Hookway C, Adam SA, Gelfand VI. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3505-14. doi: 10.1073/pnas.1505303112. Epub 2015 Jun 24.
Microtubule-dependent transport and dynamics of vimentin intermediate filaments. Hookway C, Ding L, Davidson MW, Rappoport JZ, Danuser G, Gelfand VI. Mol Biol Cell. 2015 May 1;26(9):1675-86. doi: 10.1091/mbc.E14-09-1398. Epub 2015 Feb 25.
Kinesin-1-powered microtubule sliding initiates axonal regeneration in Drosophila cultured neurons. Lu W, Lakonishok M, Gelfand VI. Mol Biol Cell. 2015 Apr 1;26(7):1296-307. doi: 10.1091/mbc.E14-10-1423. Epub 2015 Feb 5.
Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons. Del Castillo U, Lu W, Winding M, Lakonishok M, Gelfand VI. Curr Biol. 2015 Jan 19;25(2):200-205. doi: 10.1016/j.cub.2014.11.008. Epub 2014 Dec 31.
Mitochondrial membrane potential is regulated by vimentin intermediate filaments. Chernoivanenko IS, Matveeva EA, Gelfand VI, Goldman RD, Minin AA. FASEB J. 2015 Mar;29(3):820-7. doi: 10.1096/fj.14-259903. Epub 2014 Nov 17. PMID: 25404709 Free PMC Article