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Dynamics of intermediate filaments

 

Focus of our research is to understand intermediate filament (IF) dynamics. Recent publication from our group and other researcher established that IFs are not a static but undergo dynamic changes to facilitate various cellular activities such as motility, cell signalling, transport of organelles and other components. We are interested in molecular mechanisms responsible for IF dynamics and its regulation.  We are working on identification of adaptor proteins that facilitate binding of IFs to other cytoskeletal components (microtubules, actin and motor proteins) and to organelles. We are also interested in changes of IF dynamics in pathological conditions